I'm having the same issue. I'm on XP, and a couple of days ago, I noticed that files stopped opening for FrameMaker. I don't know about other apps, since this is pretty much all I use on my VM. Both double-click and single click > Open get inconsistent results. It takes multiple attempts to open the file. I reverted to an old snapshot, but that didn't fix it. It doesn't seem to be about clicking, per se; it's about opening the file. There are so many variables here, I have barely begun narowing them. I just wanted to chime in with a similar issue to see if other people are suffering too...
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